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BLT mice

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000154-30e7-ca0f-1ab5-a1ee80000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "The BLT mouse is a modification of the SCID-Hu model which was developed by Joseph McCune in the early nineties. To construct the BLT model, NOD/SCID mice are cotransplanted with human liver and thymus tissues along with autologous CD34+ hematopoietic stem cells. Development of a robust human hemato-lymphoid system is observed between 12-16 weeks post engraftment with human cells and tissues. This model is also being used extensively in HIV research and studying of virus-specific human immune responses. The BLT mice are, however, susceptible to thymic lymphoma and may not allow long term studies (average lifespan ~8.5 months)."
  2. Additional Name
    BLT humanized mice
  3. Related Disease
    Human immunodeficiency virus infectious disease
  4. Related Disease
    viral infectious disease
  5. Website(s)
    http://www.humouse.org/index.php/mouse-model/blt
  6. Parental Strain Name
    NOD/SCID
  7. Biological process studied
    Immune system process
  8. Infectious History
    cotransplanted with human liver and thymus tissues along with autologous CD34+ hematopoietic stem cells
  9. Location
    Stem Cell & Xenograft Core (Penn)
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2016-04-19T19:46:30.548-04:00
  4. creator
    fcoldren
  5. modified
    2016-04-21T12:50:30.710-04:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016