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Jax NSGS mice

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000154-30f6-608e-1ab5-a1ee80000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "The triple transgenic NSG-SGM3 (NSGS) mice expressing human IL3, GM-CSF and SCF combine the features of the highly immunodeficient NOD scid gamma (NSG) mouse with cytokines that support the stable engraftment of myeloid lineages and regulatory T cell populations. As a result, these NSG-SGM3 mice allow superior engraftment of diverse hematopoietic lineages and primary AML samples than other models and are useful for immuno-oncology, immunology and infectious disease studies."
  2. Related Disease
    disease by infectious agent
  3. Related Disease
    hematologic cancer
  4. Related Disease
    acute myeloid leukemia
  5. Website(s)
    https://www.jax.org/strain/013062
  6. Related Technique
    Xenotransplantation
  7. Biological process studied
    Immune system process
  8. Genetic Alteration(s)
    Prkdc[scid]
  9. Genetic Alteration(s)
    Il2rg[tm1Wjl]
  10. Genetic Alteration(s)
    Tg(CMV-IL3,CSF2,KITLG)1Eav
  11. Location
    Stem Cell & Xenograft Core (Penn)
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2016-04-19T20:01:04.374-04:00
  4. creator
    fcoldren
  5. modified
    2016-04-21T12:53:10.641-04:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016