GEFOS GWAS: Summary Statistics

eagle-i ID

Resource Type

Properties

1. Resource Description

   "The GEnetic Factors for OSteoporosis (GEFOS) Consortium is a large international collaboration comprising numerous prominent research groups. Osteoporosis is a common age-related complex disease with a strong genetic component. Osteoporotic fractures account for considerable disease burden and costs. The GEFOS.seq project used meta-analysis of whole genome sequencing, whole exome sequencing and deep imputation of genotype data to identify low-frequency and rare variants associated with risk of osteoporosis. Three (3) DXA-derived traits are included in this data release: Femoral Neck bone mineral density (BMD) (FN-BMD), Lumbar Spine BMD (LS-BMD), and Forearm BMD (FA-BMD)."

2. Access Restriction(s)

   Agree to the <a href="https://www.gefos.org/sites/default/files/GEFOS.seq_UK10K_BMD_GWAS_Terms_of_Use.pdf">Terms of Use</a>

3. Used by

   Voight Laboratory

4. Data Input

   Lumbar spine bone mineral density association summary statistics

5. Data Input

   Femoral neck bone mineral density association summary statistics

6. Data Input

   Forearm bone mineral density association summary statistics

7. Topic

   Homo sapiens

8. Topic

   osteoporosis

9. Related Publication or Documentation

   Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture

10. Website(s)

    http://www.gefos.org/

11. Related Technique

    SNP genotyping assay

12. Developed by

    GEnetic Factors for OSteoporosis Consortium