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Inducible Bmal1 Knockout
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/0000016c-d8f2-e89b-ca32-d9ac80000000
Resource Type
Properties
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Resource Description
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Tamoxifen inducible global Bmal1 KO.
The Bmal1f/f floxed mice were crossed with a tamoxifen-inducible universal Cre (EsrCre) mice or NestinCre mice (Jackson Laboratories, Bar Harbor, ME) to yield Bmal1f/f-EsrCre mice and Bmal1f/f-NestinCre (nKO) mice, respectively. To generate inducible Bmal1 knockout (iKO) mice, 3m old (unless specified) Bmal1f/f-EsrCre mice were treated with tamoxifen as previously described.
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Contact
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Teegarden, Sarah., PhD
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Related Publication or Documentation
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Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival
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Biological process studied
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circadian rhythm
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Location
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FitzGerald Lab
