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COX Reversa

http://eagle-i.itmat.upenn.edu/i/0000016c-e2e5-a20e-ac0d-7d5c80000000

Resource Description

COX genes switched A COX-1>COX-2 mouse strain on a mixed C57BL/6×129/Sv genetic background was established previously by replacing most of exons 1–9 of Ptgs2 with the entire Ptgs1 cDNA and cryo-recovered from JAX (#008104). These mice were backcrossed with the C57BL/6 strain for 10 generations. Cross-breeding of COX-1>COX-2 and COX-2>COX-1 mice produces Reversa mice.
Contact

Teegarden, Sarah., PhD
Related Publication or Documentation

Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions.
Location

FitzGerald Lab

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