T cell-specific COX2 Knockout

eagle-i ID

Resource Type

Properties

1. Resource Description

   CD4/COX2 KO Mice with the COX-2 gene flanked with 2 LoxP sites, COX-2f/f mice on a mixed 129Sv/B6 background (∼75% B6, ∼25% 129Sv) were crossed with B6 CD4Cre mice (Taconic, Hudson, NY) to obtain CD4Cre/COX-2f/+ mice, which then were backcrossed with COX-2f/f to create CD4Cre/COX-2f/f mice. These mice were crossed with COX-2f/f to generate CD4Cre/COX-2f/f mice as T cell-specific COX-2-deficient mice (TCKOs).

2. Contact

   Teegarden, Sarah., PhD

3. Related Disease

   cardiovascular system disease

4. Related Publication or Documentation

   Targeted Deletions of Cyclooxygenase-2 and Atherogenesis in Mice

5. Biological process studied

   Regulation of biological process

6. Location

   FitzGerald Lab