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T cell-specific COX2 Knockout
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/0000016c-e331-f657-ac0d-7d5c80000000
Resource Type
Properties
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Resource Description
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CD4/COX2 KO
Mice with the COX-2 gene flanked with 2 LoxP sites, COX-2f/f mice on a mixed 129Sv/B6 background (∼75% B6, ∼25% 129Sv) were crossed with B6 CD4Cre mice (Taconic, Hudson, NY) to obtain CD4Cre/COX-2f/+ mice, which then were backcrossed with COX-2f/f to create CD4Cre/COX-2f/f mice. These mice were crossed with COX-2f/f to generate CD4Cre/COX-2f/f mice as T cell-specific COX-2-deficient mice (TCKOs).
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Contact
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Teegarden, Sarah., PhD
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Related Disease
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cardiovascular system disease
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Related Publication or Documentation
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Targeted Deletions of Cyclooxygenase-2 and Atherogenesis in Mice
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Biological process studied
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Regulation of biological process
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Location
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FitzGerald Lab
