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Bioanalytical Core laboratory (CHOP)

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000016d-abab-e127-9b41-3c2f80000000

Resource Type

  1. Core Laboratory

Properties

  1. Resource Description
    The Bioanalytical Core (BCL-CORE) laboratory is a part of the newly established Center for Clinical Pharmacology. The Bioanalytical Core provides quantitative bioanalytical services (analysis of small molecule drugs, metabolites and biomarkers in blood, serum, plasma, urine, ultrafiltrate, micro-dialysate, dried blood spot (DBS) and tissue homogenates) that are used for drug discovery and development. The Bioanalytical Core performs method validations, partial validations, cross-matrix validations, or combination of them required to meet project needs. Validation studies are performed in accordance with the US FDA Guidance for Industry, Bioanalytical Method Validation. The core has developed assays for investigational and marketed drugs used for pain, oncology, cardiology and infectious diseases. These assays are typically used to support pediatric drug discovery and development. Validated Assays: -- Dexmedetomidine -- Cefazolin -- Cefepime -- Fluconazole -- Amicar -- Midazolam and 1 and 4-hydroxymidazolam metabolites -- Morphine, morphine-3-glucuronide and morphine-6-glucuronide -- Ketamine and Norketamine -- Milrinone -- Actinomycin D -- Vincristine -- Alisertib (MLN8237) -- Efavirenz -- Aprepitant (EMEND IV) -- Tenofovir
  2. Additional Name
    BCL-CORE
  3. Affiliation
    Center for Clinical Pharmacology
  4. Website(s)
    https://bioanalytical.research.chop.edu/
  5. Director
    Moorthy, Ganesh S., PhD
  6. Director
    Zuppa, Athena F., MD, MSCE
  7. Secondary affiliation
    The Children's Hospital of Philadelphia Research Institute
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    ggrant (Gregory Grant)
  3. created
    2019-10-08T10:09:13.789-04:00
  4. creator
    ggrant (Gregory Grant)
  5. modified
    2020-02-10T14:29:48.353-05:00
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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016