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Recombinant Adeno-Associated Viral Vectors

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000016d-b6df-1448-13a2-808d80000000

Resource Type

  1. Material production service

Properties

  1. Resource Description
    With access to a wide range of host organisms, long-term expression in vivo, and low immunogenicity, recombinant Adeno-Associated viral vectors (rAAV) offer a robust and proven method of gene delivery. rAAV is a single stranded DNA parvovirus that infects both dividing and non-dividing cells with varying tissue tropisms and transduction efficiencies. It is highly popular in both the pre-clinical and clinical settings, capable of producing high titers for transgenes at maximum cassette limits of 4.7kb for single stranded vectors, and 2.2kb for self-complementary vectors. Our facility is equipped to manufacture rAAV at large scales with a production capacity of 2.0 x 1012 - 3.0 x 1015 viral genomes per week and can purify and concentrate vectors up to 1-5 x 1013vg/ml. Optimized for enhanced transduction efficiency and purified via CsCl gradient centrifugation, our final product contains over 99% packed capsid to ensure the highest effective potency in your application.
  2. Service Provided by
    Research Viral Vector Core (CHOP)
  3. Website(s)
    https://rvc.research.chop.edu/recombinant-adeno-associated-viral-vectors
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    ggrant (Gregory Grant)
  3. created
    2019-10-10T14:14:21.187-04:00
  4. creator
    ggrant (Gregory Grant)
  5. modified
    2019-10-10T14:15:57.213-04:00
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016