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Recombinant Adeno-Associated Viral Vectors

eagle-i ID


Resource Type

  1. Material production service


  1. Resource Description
    With access to a wide range of host organisms, long-term expression in vivo, and low immunogenicity, recombinant Adeno-Associated viral vectors (rAAV) offer a robust and proven method of gene delivery. rAAV is a single stranded DNA parvovirus that infects both dividing and non-dividing cells with varying tissue tropisms and transduction efficiencies. It is highly popular in both the pre-clinical and clinical settings, capable of producing high titers for transgenes at maximum cassette limits of 4.7kb for single stranded vectors, and 2.2kb for self-complementary vectors. Our facility is equipped to manufacture rAAV at large scales with a production capacity of 2.0 x 1012 - 3.0 x 1015 viral genomes per week and can purify and concentrate vectors up to 1-5 x 1013vg/ml. Optimized for enhanced transduction efficiency and purified via CsCl gradient centrifugation, our final product contains over 99% packed capsid to ensure the highest effective potency in your application.
  2. Service Provided by
    Research Viral Vector Core (CHOP)
  3. Website(s)
Provenance Metadata About This Resource Record
  1. workflow state
  2. contributor
    ggrant (Gregory Grant)
  3. created
  4. creator
    ggrant (Gregory Grant)
  5. modified
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016