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Small Animal Model of HIV-1 Infection

eagle-i ID


Resource Type

  1. Support service


  1. Resource Description
    The Penn CFAR Immunology Core is partnered with the Xenograft and Stem Cell Core to provide "ready-to-use" NSG and BLT mice, experimental planning and design, IACUC protocols, and in vivo experimental techniques. Robust human T cell engraftment was developed in 2005 using mice engineered to have common gamma chain deficiency, the Nod, SCID, common gamma chain deficient (NSG) mouse. This model has been used to study approaches like ZFN targeting coreceptors and anti-sense RNA to protect fully mature CD4 T cells from HIV-1 infection in vivo. As an important priority for the coming cycle, the Penn CFAR Immunology Core has been working with Xenograft and Stem Cell Core to establish the next generation humanized mouse model, the Bone marrow-Liver-thymus (BLT) humanized mouse. With support from the CFAR, the Xenograft Core monitors engraftment to determine when the mice are ready to use, at which point the mice are transferred to the investigator's protocol. In addition to producing "ready-to-use" BLT and NSG mice, the Core can further support users by performing a wide variety of in vivo techniques including injections of live HIV virus, human T-cells, peripheral blood sampling and tissue collection. The Core Director is also able to assist CFAR investigators with experimental planning, experimental design, and IACUC protocols.
  2. Service Provided by
    Immunology Core
  3. Website(s)
Provenance Metadata About This Resource Record
  1. workflow state
  2. contributor
    ggrant (Gregory Grant)
  3. created
  4. creator
    ggrant (Gregory Grant)
  5. modified
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016