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Chemical Genomics/Organism HTS

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Resource Type

  1. Material analysis service


  1. Resource Description
    Model organisms such as C. elegans, drosophila, and zebrafish have helped define the underpinnings of modern biology with critical impact in neurology, stem cells, embryo development, morphogenesis, multi-organ physiology and toxicology, lifespan control and ageing. Organism-based chemical genomics allows unbiased genome wide exploration of target space. While the human genome is fully available, only half of human genes have any report whatsoever in the literature, and fewer than 2000 have five or more papers associated with them. This means that over half the target space for chemical discovery is largely untapped. Through the use of model organisms, the vision of the PCMD is to leverage organism-based, genome-wide research to bring new targets for chemical HTS. Special emphasis is placed on organism-based platforms that are HTS compatible. Central to this vision is the rapid translation of discovery in model organisms to mammalian HTS/probe production. Chemical Genomics: John Hogenesch, PhD The combination of genomic cell based screening approaches and chemical biology offers new opportunities to both define targets and their modulators. As part of the PCMD, we are taking these approaches to delineate important signal transduction pathways, determine new components, and perturbagens that modulate them. Viral Genome/Host Interactions: Sara Cherry, PhD C. Elegans Discovery: Todd Lamitina, PhD Zebrafish Discovery: Michael Pack, PhD
  2. Contact
    Pack, Michael., MD
  3. Contact
    Hogenesch, John B., PhD
  4. Contact
    Cherry, Sara., PhD
  5. Service Provided by
    Penn Center for Molecular Discovery
  6. Website(s)
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  2. contributor
    ggrant (Gregory Grant)
  3. created
  4. creator
    ggrant (Gregory Grant)
  5. modified
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016