Biomarker Core

eagle-i ID

Resource Type

Properties

1. Resource Description

   The Biomarker Core has two over-arching goals: Continue a highly-successful tradition at the University of Pennsylvania of banking and widely dispersing biofluid samples obtained by the Clinical Core, while annotating these samples with baseline molecular measures that allow for Amyloid-Tau-Neurodegeneration (A/T/(N)) classification within the NIA-AA framework. Pave new ground by relating well-established CSF- and imaging-based A/T/(N) biomarkers to measures obtained from emerging plasma-based biomarkers, and performing measures that will allow for investigation of the contribution of vascular disease to heterogeneity of clinical phenotype. To achieve these goals, the Biomarker core aims to: Oversee and direct all banking and dispersal of biofluid samples obtained in ADRC UDS participants Characterize established biochemical biomarkers previously reported in the literature in order to annotate all Clinical Core samples within the A/T/(N) classification scheme. Relate emerging plasma-based biomarkers to established CSF and imaging biomarkers, as well as neuropathology. Collaborate with other Cores to investigate the contribution of vascular disease to heterogeneity of clinical phenotype. Provide advice and support to investigators within and outside the Penn ADRC.

2. Contact

   Chen-Plotkin, Alice., MD

3. Service Provided by

   Alzheimer’s Disease Research Center

4. Website(s)

   https://www.med.upenn.edu/adrc/cores.html