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Biomarker Core

eagle-i ID


Resource Type

  1. Support service


  1. Resource Description
    The Biomarker Core has two over-arching goals: Continue a highly-successful tradition at the University of Pennsylvania of banking and widely dispersing biofluid samples obtained by the Clinical Core, while annotating these samples with baseline molecular measures that allow for Amyloid-Tau-Neurodegeneration (A/T/(N)) classification within the NIA-AA framework. Pave new ground by relating well-established CSF- and imaging-based A/T/(N) biomarkers to measures obtained from emerging plasma-based biomarkers, and performing measures that will allow for investigation of the contribution of vascular disease to heterogeneity of clinical phenotype. To achieve these goals, the Biomarker core aims to: Oversee and direct all banking and dispersal of biofluid samples obtained in ADRC UDS participants Characterize established biochemical biomarkers previously reported in the literature in order to annotate all Clinical Core samples within the A/T/(N) classification scheme. Relate emerging plasma-based biomarkers to established CSF and imaging biomarkers, as well as neuropathology. Collaborate with other Cores to investigate the contribution of vascular disease to heterogeneity of clinical phenotype. Provide advice and support to investigators within and outside the Penn ADRC.
  2. Contact
    Chen-Plotkin, Alice., MD
  3. Service Provided by
    Alzheimer’s Disease Research Center
  4. Website(s)
Provenance Metadata About This Resource Record
  1. workflow state
  2. contributor
    ggrant (Gregory Grant)
  3. created
  4. creator
    ggrant (Gregory Grant)
  5. modified
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016