Although there have been major advances in Psychiatry and Neurology, less progress has been made toward understanding nervous system function, specifically the mechanisms underlying behavior. The Penn Medicine Neuroscience Center (PMNC), the Institute for Translational Medicine and Therapeutics (ITMAT), the Center for Sleep and Circadian Neurobiology (CSCN) and the Perelman School of Medicine(PSOM) established the Neurobehavior Testing Core (NTC) for behavioral phenotyping of mice. In addition to serving as a resource for neuroscience researchers, the NTC can be utilized by scientists in other disciplines who are interested in the behavioral consequences of other physiological (e.g., metabolic) disruption.
The NTC offers comprehensive testing of mouse models of disease and experimental compounds. Investigators can select from a broad range of assays that can be tailored to their specific interests. Our assays include tests for Learning and Memory, Circadian and home-cage activity monitoring, Affective disorder-related behaviors, Social interaction, Sensory and Motor function, Drug addiction-related behaviors and electrophysiological recording. The NTC also provides consultation, assistance in writing protocols and data analysis. The NTC can train personnel from an investigator’s lab to perform experiments at a reduced cost. Please contact Dr. W. “Tim” O’Brien at firstname.lastname@example.org or (215) 898-0476 to discuss how the Neurobehavior Testing Core could facilitate your research.
Faraday chambers with software for EEG recordings
Spontaneous object recognition tasks and novel object recognition tasks
Procedure rooms can be used for tissue harvesting.
The core has a full small animal surgery suite with a stereotactic set-up.
submergible Y-maze also available
Two elevated zero mazes
The core provides consultation on study design including appropriate tests, mouse line/strain, numbers of animals, control groups and breeding strategies. The core will also provide consultation regarding ULAR, IACUC and other regulatory issues.
The core can train your lab personnel to perform behavioral tests in the facility.
Ultrasonic Vocalization Recording
VonFrey touch test
Open Field Activity
Hole Board Exploration
Two Bottle Choice Test
Elevated Zero Maze Y Maze Test
Forced Swim Test
Acoustic Startle/PrePulse Inhibition
EEG electrode placement
Morris Water Maze
Object Recognition Tasks
Reversal of Learning
Cross maze learning
SubQ, i.p. and gavage
Including CNS dissection by region