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Ultrasound Research Laboratory (Penn)

Director: Sehgal, Chandra (Sandy) M., Ph.D.

Summary:

The goals of the research laboratory are:

• To develop new ultrasound technologies and clinical applications
• To bridge the gap between technology and clinical applications
• To provide ultrasound imaging resources to other research groups within the Penn community and in other institutions

The laboratory consists of a core group of scientists, sonographers and technicians with expertise in ultrasound technology and computer programming. This group works with clinicians in multiple specialties; including radiologists, cardiologists and surgeons. Ultrasound Research Services, an arm of the laboratory, furnishes a state-of-the-art ultrasound scanner dedicated to research and serves the research community. There is a full-time sonographer and a part-time radiologist on staff to conduct clinical and pre-clinical imaging.

The research laboratory has been a valuable resource to several groups working on diverse projects. These include studies involving the measurement of angiogenesis, vascularity, tissue elasticity, contrast agents, and the effects of various physical and pharmaceutical agents on blood flow and tissue vascularity. The studies span a range of clinical areas including research on cancer, cardiovascular disease and musculoskeletal disease.

Affiliations:

People:

    Member: Coleman, Beverly, MD
    Role: Professor, Department of Radiology, Section Chief, Ultrasound Division, Department of Radiology

    Member: Schultz, Susan M., RDMS
    Role: Research Ultrasonographer, Department of Radiology

Resources:

Services

  • Contrast enhanced sonography ( Analysis service )

    For clinical research, small animal studies, and large animal studies

    "The use of micro-bubble based contrast agents for enhancing ultrasound images is now FDA approved for cardiac imaging, and being evaluated for other clinical applications. Ultrasound Research Services has the resources necessary for performing this type of imaging in both fundamental and harmonic modes and the capability for both qualitative and quantitative assessment of such images."

  • Image analysis service ( Data analysis service )

    "A unique feature of the laboratory is its comprehensive set of software and hardware tools developed in-house for quantitative image analysis. The laboratory is equipped with electronic devices for making acoustic measurements on tissue and biological samples, including contrast agents. There are also facilities for frame-by-frame computer analysis of real-time ultrasound images allowing for analysis of data acquired at multiple sites using different scanners.

    A software package developed in-house analyzes large sets of sonographic and Doppler images; measuring changes in flow, perfusion and grayscale. The cross-sectional boundaries of blood vessels can be measured by semi-automated analysis of ultrasound images and used to study vascular biology. These tools are of special interest to those involved in evaluating the kinetic response of drugs and pharmaceuticals. Another set of tools currently being developed characterizes tumor margins, shapes and grayscale characteristics. The goal is to use these features in conjunction with neural net and log regression algorithms for computer-aided diagnosis."

  • Imaging large animals ( Analysis service )

    "Gray-scale, color Doppler and power Doppler imaging is available. The imaging can be performed at multiple frequencies using different ultrasound probes. At selected frequencies, imaging can be performed in both fundamental and harmonic modes."

  • Imaging small animals ( Analysis service )

    "Gray-scale, 3D, M-Mode, color Doppler and power Doppler imaging are available using frequencies ranging from 12 MHz to 55 MHz. The latest high frequency technology is available with linear transducers ranging from 21 MHz to 55 MHz. Interventional assistance can be provided with great resolution and accuracy in extremely small and difficult cases."

  • Measuring blood flow ( Analysis service )

    For clinical research, small animal studies, and large animal studies

    "Power Doppler is available to evaluate perfusion of a variety of tissue types. Spectral Doppler imaging can provide a variety of measures and indices in both arterial and venous flow."

  • Measuring tissue motion ( Analysis service )

    For clinical research, small animal studies, and large animal studies

    "M-mode imaging is available for measuring tissue motion in cardiac and other applications."

  • Organ specific ultrasound for clinical research ( Analysis service )

    "A variety of organs can be evaluated using ultrasound. Many clinical studies require anatomical evaluation of organs such as the liver, kidneys, spleen, gall bladder, thyroid, uterus, ovaries, testis and/or prostate, as pre-inclusion criteria or as a part of the continuing research. Additional uses of ultrasound include pre-op anatomical evaluations, organ evaluation while on medications and study completion evaluations."

  • Photoacoustic imaging of small animals ( Analysis service )

  • Ultrasound research services ( Material analysis service )

    "Ultrasound Research Services, an arm of the laboratory, furnishes a state-of-the-art ultrasound scanner dedicated to research and serves the research community. There is a full-time sonographer and a part-time radiologist on staff to conduct clinical and pre-clinical imaging."

Software

  • In-house software for quantitative analysis of images ( Software )

    "All the ultrasound images used for research purposes are taken in loops. When video tape is used, there is a facility for labeling individual frames on the tape and digitizing them frame by frame for computer analysis. An extensive software package has been developed in-house that allows semi-automated analysis of large data sets (up to 10,000 images per set) of sonographic and Doppler images. This resource allows monitoring of flow and gray-scale changes at a temporal resolution of 30 ms. The software also has a large set of tools for measuring regional and global changes in vascularity and gray scale texture. This computer program is particularly suited for evaluating the kinetic response of the organs to pharmaceuticals."


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Last updated: 2016-05-16T12:51:03.549-04:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016