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Small Animal Imaging Facility: MRI/MRS Sub-Core (Penn)

Director: Pickup, Stephen, Ph.D.

Summary:

These studies are performed on a wide range of biological samples including small animals (cats, rabbits, rats, mice), tissue specimens, cultured cells and tissue extracts.

This facility includes a conveniently located, well equipped surgery room used for preparing the animals for MR exams and a wide assortment of supporting equipment, i.e. anesthesia machines, MR compatible vital signs monitors (SA Instruments), infusion pumps (Harvard), heating pads, etc. A variety of perishable supplies used in animal preparation are also provided by the facility.

Affiliations:

People:

    Member: Liu, Weixia, Ph.D.
    Role: Lab Manager, MRI/MRS Sub-Core, Small Animal Imaging Facility

    Member: Mancuso, Anthony, PhD
    Role: Director, Laboratory for NMR Spectroscopy of Cellular Metabolism

Resources:

Instruments

  • 4.7T horizontal bore MR spectrometer ( MRI Scanner )

    "4.7 Tesla 50 cm horizontal bore MR System: (Small Animal Imaging Lab 1st Floor of SCTR) equipped with 30 cm ID 3 gauss/cm and a 12 cm ID 25 gauss/cm gradient tube and interfaced to an Agilent DirectDrive console. The console is configured with two broad band channels as well as a 4 channel receiver array. A variety of volume and surface coils suitable for imaging of rodents are also available."

  • 9.4T horizontal bore MR spectrometer ( MRI Scanner )

    "9.4 Tesla 31 cm horizontal bore MR System: (B100 John Morgan Building) equipped with a 21 cm ID 25 gauss/cm and a 12 cm ID 40 gauss/cm gradient tube and interfaced to an Agilent DirectDrive console."

  • 9.4T vertical bore MR spectrometer ( MRI Scanner )

    "9.4 Tesla 8.9 cm vertical bore MR System: (Small Animal Imaging Lab 1st Floor of SCTR) equipped with 55 mm ID 100 gauss/cm gradient tubes and interfaced to an Agilent DirectDrive console. The console is configured with full imaging capabilities, three transmit/receive channels (one high band and two low band), variable temperature control, sample insert and eject capabilities, and liquids and solids probes suitable for generation of high-resolution spectra. Numerous slotted tube resonators suitable for imaging and spectroscopy of subcutaneous tumors and tissue specimens are also available."

Services

  • MR spectrometer access ( Access service )

    "Users interested in utilizing the SAIF MR resources are encouraged to contact the director of the facility, S. Pickup (see below for contact information) in order to discuss protocol design before completing the SAIF research application. The prospective user then completes and submits a SAIF Research Applications form which is reviewed by the relevant core directors. Upon receiving approval of the application, the investigator must contact a member of the staff of the MR facility in order to create user accounts on the target platform and scheduling calendar. Users with sufficient experience may schedule studies, prepare animals and perform scans with minimal support from the staff. Less experienced users may opt to have the scans performed by facility staff on a fee for service basis."

  • Small animal MR scanning ( Material analysis service )

    Scans are performed by facility staff on a fee for service basis.


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Last updated: 2016-04-28T11:41:52.106-04:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016