Research in my laboratory focuses on the interrelationship between energy stores and regulation of energy balance by the brain. Contrary to the prevailing view of the adipocyte as merely a specialized cell for the storage of excess energy in the form of triglycerides, there is increasing evidence that adipose tissue plays a more active role in energy homeostasis. The levels of leptin, adiponectin, resistin and other hormones secreted by adipose tissue are dependent on the status of energy balance, and serve as important signals linking energy stores to peripheral and central homeostatic mechanisms. Adipokines also have profound effects on the neuroendocrine axis, and glucose and lipid metabolism.
"Breeder Npy+/− mice on a mixed 129SvEv-C57Bl/6J background were backcrossed for 10 generations onto the C57BL/6J background. Heterozygotes were then bred to each other to generate NPYko mice and wild-type controls."
"Breeder Npy+/− mice on a mixed 129SvEv-C57Bl/6J background were provided by Richard Palmiter (University of Washington, Seattle, WA)."