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Positron Emission Tomography Center (Penn)

Directors: Mankoff, David, MD, PhD; Pryma, Daniel, MD

Summary:

The PET Center is dedicated to continuing the advancement of molecular imaging and seeks to build a network of collaborators to conduct translational research using existing and new radiotracers to help better understand the diagnosis, physiology and treatment of multiple diseases.

We strive to educate referring clinicians and their patients about the emerging benefits of PET/CT diagnostic procedures, other radiotracer imaging methods and radionuclide therapies as tools in their research and clinical practice.

The PET Center is committed to providing opportunities and mentoring for individuals interested in pursuing work or collaborations within the molecular imaging field.

Affiliations:

People:

Resources:

Instruments

  • Philips Allegro PET scanner ( Positron emission tomography scanner )

    "The Allegro is a PET-only instrument with an intrinsic spatial resolution of 4.8 mm. The scanner operates in 3D (no septa) utilizing a fully 3D iterative algorithm (3D-RAMLA) for image reconstruction.

    The GSO crystals achieve 16% energy resolution. Attenuation correction relies on a transmission scan performed in singles acquisition mode using a Cs-137 point source.

    Philips Allegro
    Philips Medical Systems
    Reconstructed FOV: 25.6, 57.6 cm
    Axial FOV: 18 cm
    Detector Design: 4x6x20mm GSO crystals
    Spatial Resolution: 4.8 mm FWHM (NEMA)
    Installed at HUP in 2001"

  • Philips Gemini TF PET/CT Scanner ( Positron emission tomography scanner )

    "The Philips PET/CT Gemini systems have an intrinsic spatial resolution of 4.7 mm, and LYSO crystals that lead to improved energy resolution of 12% and higher sensitivity than the previous GSO systems. A system timing resolution of approximately 600 ps is achieved with these faster crystals, enabling time-of-flight (TOF) measurement.

    Gemini TF (Standard Bore)
    Philips Medical Systems
    Patient Port (Bore): 70 cm
    Reconstructed FOV: 25.6, 57.6, or 67.6 cm
    Axial FOV: 18 cm
    Detector Design: 4 x 4 x 22 mm LYSO crystals
    Spatial Resolution: 4.7 mm FWHM (NEMA)
    Installation 2005 (HUP)

    Gemini TF (Big Bore)
    Philips Medical Systems
    Patient Port (Bore): 85 cm
    Reconstructed FOV: 25.6, 57.6, or 67.6 cm
    Axial FOV: 18 cm
    Detector Design: 4 x 4 x 22 mm LYSO crystals
    Spatial Resolution: 4.7 mm FWHM (NEMA)
    Installation 2009 (PCAM)

    The Big Bore is housed in Radiation Oncology and is operated jointly with Radiation Oncology."

  • Philips Ingenuity TF PET/CT Scanner ( Positron emission tomography scanner )

    "The 64-slice Ingenuity CT scanner provides attenuation correction, anatomical registration, and features iDose, an iterative reconstruction technique that allows for low dose CT acquisition, producing high image quality with reduced artifacts.

    Ingenuity TF (Standard Bore)
    Philips Medical Systems
    Patient Port (Bore): 70 cm
    Reconstructed FOV:
    Axial FOV: 18 cm
    Detector Design: 4 x 4 x 22 mm LYSO crystals
    Spatial Resolution: 4.7 mm FWHM (NEMA)
    Installation 2013 (PCAM)"

  • Siemens Biograph mCT Scanner ( Computed tomography scanner )

    "Image reconstruction utilizes the ML-EM list-mode algorithm and includes TOF information and physical data corrections (e.g. scatter, attenuation). The 16-slice Brilliance CT scanner provides attenuation correction and anatomical registration.

    Biograph mCT
    Siemens
    Patient Port (Bore): 78 cm
    Reconstructed FOV:
    Axial FOV: 16.2 cm
    Detector Design: 4 x 4 x 20 mm LSO crystals
    Spatial Resolution: 4.5 mm FWHM (NEMA)
    Installation (PCAM)

    The mCT system is largely used for clinical studies and clinically oriented research."

Services

  • Cyclotron Facility radiopharmaceutical production service ( Material production service )

    "The cyclotron facility was built in 1985 and is a below grade building originally containing approximately 5100 square feet of space with a Japan Steel Works (JSW) BC3015, 30 MeV cyclotron. The JSW is capable of accelerating p, d, 3He, and 4He. The machine energy is variable with three pre-sets. For protons, the energies are 15, 22, and 30 MeV. Typical beam currents are 10-20 µA, with a maximum current capability of 30-40 µA.

    In 2010, an IBA 18/9 MeV Cyclone machine was installed in an expanded vault next to the existing JSW cyclotron, increasing the overall laboratory space to just over 8000 square feet. The addition of the IBA greatly enhances our ability to produce a larger number of radiotracers for PET research studies. Higher beam currents are available with the new cyclotron versus the JSW. Also, 18F-- production yields increase from 2 Ci to 12 Ci and 11C yields of 3 Ci are achieved in approximately half the time as compared to the JSW. Deuteron production of 18F2 is approximately twice the JSW capacity (300 mCi vs. 150 mCi) due mainly to the higher current of the deuteron beam from the IBA machine. In addition, the IBA has a “double shot” target capable of producing 1.2 Ci of 18F2 in approximately 90 minutes. Current radiopharmaceutical production includes 11C, 13N, 15O, and 18F (both gas and liquid forms).:

    The list of radiopharmaceuticals available from the Cyclotron Facility include: 11C-Carfentanil, 11C-PIB, 18F-AV45, 18F-FDG, 18F-FHBG, 18F-FMISO, 18F-Flutemetamol, 18F-Me-Choline, 18F-FLT, 99mTc-Trodat, 3H-Cholesterol, and 123I-ADAM.

  • Standard Brain PET/CT for FDG ( Analysis service )

    • Uptake Time: 30 min
    • Patient Positioning: Head first, supine, using a head holder, making sure the cantho‐meatal plane line is vertical. Arms crossed over the chest/abdomen or at sides (for patient comfort).
    • Scan Length: Single bed position that includes the entire brain
    • Scan Duration: 10 min
    • Scan Direction: N/A, single bed position

  • Standard Torso Survey PET/CT for FDG ( Analysis service )

    • Uptake Time: 60 min
    • Patient Position: Head first, supine, arms above the head (for optimal thoracic imaging)
    • Scan Length: Base of skull to the mid-thigh (from just inferior to the eyes to between the pelvis and the knees)
    • Scan Duration: 15–30 min (~8–10 bed positions)
    • Scan Direction: from Head toward feet)

  • Standard Whole Body PET/CT for FDG ( Analysis service )

    • Uptake Time: 60 min
    • Patient Positioning: Head first, supine with arms crossed low over the abdomen (allows the entire body, including arms, to be scanned)
    • Scan Length: Top of the head to the tip of the toes (typically a single scan, may be split into 2 scans for tall people)
    • Scan Duration: 35–50 min
    • Scan Direction: From head toward feet


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Last updated: 2016-05-16T13:02:32.285-04:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016