eagle-i University of PennsylvaniaUniversity of Pennsylvania
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Kazazian Laboratory

Summary:

Research Interests
-- Population genetics of active L1 retrotransposons in humans.
-- Individual differences in retrotransposition capability have global effects on genome diversity and human evolution.
-- A mouse model of human L1 retrotransposition as a tool for insertional mutagenesis and discovery of gene function.
-- The SVA element is a non-autonomous retrotransposon that can cause disease
-- Preclinical trials of AAV-mediated gene therapy of hemophilia A in mice and dogs.

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Organisms and Viruses

  • FactorVIII knockout mice ( Mus musculus )

    "Male HA exon 16 knockout mice on a C57BL/6/129Sv background were generated by insertion of a neo gene into the 3’ end of exon 16"


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Last updated: 2019-12-11T15:01:40.184-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016