The PennCHOP Microbiome Program supports research across a wide spectrum of topics, with the goal of devising methods for improving human health by manipulating microbial populations. Teams at UPenn and CHOP were leaders in the Human Microbiome Project, the largest project in the history of microbiology. Studies are now expanding to link up microbiome research with myriad diverse areas of basic, translational and clinical research.
Microbiome research at Penn and CHOP includes analysis of multiple human body sites including gut, airway and skin. Microbiome studies have also been carried out extensively using animal models, including germ free (gnotobiotic) mice. Additional ongoing projects seek to translate insights in microbiome analytical methods to clinical diagnosis.