As a Center within the Perelman School of Medicine (PSOM) at the University of Pennsylvania, the Penn Medicine Translational Neuroscience Center (PTNC) is dedicated to accelerating and translating discoveries to transform the prevention, diagnosis and treatment of neuropsychiatric and neurological conditions. This year, we held an inaugural PTNC scientific retreat that included 30 basic and clinical neuroscientists across 16 departments and 4 schools at Penn. Generating a collective vision for the neurosciences, the group identified key research priorities that have the greatest potential to transform patient care. Based on this discussion, we identified two thematic areas that provided the focus for the first round of requests for applications a new Translational Neuroscience Initiative (TNI): (1) modulation of neural circuits for preventive health behaviors or recovery from neuropsychiatric or neurological disease, and (2) neuroimmune mechanisms and treatment for neuropsychiatric or neurological disease. In addition, the PTNC is working closely with Penn’s new Institute for Bioinformatics to create a neuro-informatics infrastructure to support translational research, and is developing a Translational Neuroscience Pipeline that facilitates industry partnerships. PTNC is also partnering with the Mahoney Institute for Neurosciences to enhance integration and synergies across the neurosciences at Penn. We welcome faculty within Penn’s neuroscience community to become members of the PTNC, and look forward to working with you to promote translational neuroscience research at Penn.