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Cyclotron Facility (Penn)

Director: Mach, Robert H., PhD

Summary:

One of the cyclotrons is a Japan Steel Works (JSW) BC3015 30 MeV machine, capable of accelerating protons, deuterons, 3He, and 4He. Beam currents of 10-20 mA are typical with a maximum current capability of 60 mA. In 2009, an IBA 18/9 MeV Cyclone cyclotron was added into an expanded vault adjacent to the existing JSW cyclotron. The second cyclotron provides for higher beam currents than are available on the JSW cyclotron. As a result, the 18FF- production yield increases from 2 Ci to 12 Ci and; 11CCO2 yield increases from 3 Ci to 4 Ci, thereby increasing yields of research radiotracers. While the JSW can only irradiate one target at a time, the IBA is capable of irradiating two targets simultaneously and has been the main workhorse cyclotron. In addition to 18FF- production, this cyclotron is also used for 18FF2 bombardment for electrophilic radiosyntheses. Despite its older design and lower yields, the JSW has an advantage of a higher particle energy and capability to produce alpha particles; this is a rare and valuable asset and enables our facility to produce novel radionuclides for biomedical research. In particular, the JSW currently is used to produce At-211, a radionuclide that has potential in targeted systemic radiotherapy.

The facility is divided into two sections: a clinical production laboratory where the radiopharmaceuticals used in routine diagnostic scans and clinical studies are produced, and a multiuse research area in which new radiotracers are developed for cell studies, animal studies and other research uses."

"The clinical production laboratory is operated under cGMP regulations.

People:

Resources:

Instruments

  • IBA 18/9 MeV Cyclone cyclotron ( Cyclotron )

    "The second cyclotron provides for higher beam currents than are available on the JSW cyclotron. As a result, the [18F]F- production yield increases from 2 Ci to 12 Ci and; [11C]CO2 yield increases from 3 Ci to 4 Ci, thereby increasing yields of research radiotracers. While the JSW can only irradiate one target at a time, the IBA is capable of irradiating two targets simultaneously and has been the main workhorse cyclotron. In addition to [18F]F- production, this cyclotron is also used for [18F]F2 bombardment for electrophilic radiosyntheses."

  • Japan Steel Works (JSW) BC3015 30 MeV ( Cyclotron )

    "One of the cyclotrons is a Japan Steel Works (JSW) BC3015 30 MeV machine, capable of accelerating protons, deuterons, 3He, and 4He. Beam currents of 10-20 mA are typical with a maximum current capability of 60 mA."

Services

  • Radiopharmaceutical production service ( Material production service )

    The following table lists the radiopharmaceuticals that are produced on routine basis.

    Name of the radiopharmaceuticalStatusApplication
    [18F] Fludeoxyglucose Injection ([18F] FDG)ANDARoutine diagnostic scans
    [11C] AcetateINDCardiac, cancer metabolism
    [18F] Fluorothymidine ([18F]FLT)INDCancer; cell proliferation
    [3H] CholesterolIND
    [18F] ISO-1INDCancer; cell proliferation
    [18F] Fluortriopride ([18F] FTP)INDD3 specific brain agent
    [18F] Fluoroestradiol ([18F] FES)INDCancer; estrogen status
    [18F] FluorThanatrace ([18F] FTT)INDCancer; PARP activation
    [18F] EF5INDCancer; Hypoxia agent
    [18F] FluorodopaINDHyperinsulinism, brain dopamine level
    [18F] 5-fluorodeoxycyctidineINDCancer; cell differentiation
    [11C] GlutaminePre-clinicalCancer metabolism
    [18F] 2S,4R)4-Fluoroglutamine ([18F] 4F-Gln)Pre-clinicalCancer metabolism
    [18F] DHEPre-clinicalROS status


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Last updated: 2016-06-15T15:34:28.114-04:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016