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Genetic Investigation of ANthropometric Traits Consortium

Summary:

The Genetic Investigation of ANthropometric Traits (GIANT) consortium is an international collaboration that seeks to identify genetic loci that modulate human body size and shape, including height and measures of obesity. The GIANT consortium is a collaboration between investigators from many different groups, institutions, countries, and studies, and the results represent their combined efforts. The primary approach has been meta-analysis of genome-wide association data and other large-scale genetic data sets. Anthropometric traits that have been studied by GIANT include body mass index (BMI), height, and traits related to waist circumference (such as waist-hip ratio adjusted for BMI, or WHRadjBMI). Thus far, the GIANT consortium has identified common genetic variants at hundreds of loci that are associated with anthropometric traits.

Resources:

Databases

  • GIANT GWAS 2010-2013 Summary Statistics: BMI ( Database )

    Summary data from the GIANT consortium 2010-2013 meta-analyses of Genome-wide Association (GWA) data include p-values and direction of effect at over 2 million directly genotyped or imputed single nucleotide polymorphisms (SNPs). Allele frequency data was not released to prevent the possibility of identifying individuals from the summary results.

    Associations between body mass index (BMI) and ~ 2.8 million SNPs in up to 123,865 were examined with targeted follow up of 42 SNPs in up to 125,931 additional individuals.

  • GIANT GWAS 2010-2013 Summary Statistics: Height ( Database )

    Summary data from the GIANT consortium 2010-2013 meta-analyses of Genome-wide Association (GWA) data include p-values and direction of effect at over 2 million directly genotyped or imputed single nucleotide polymorphisms (SNPs). Allele frequency data was not released to prevent the possibility of identifying individuals from the summary results.

    Associations between height and 2,834,208 single nucleotide polymorphisms (SNPs) present in the HapMap Phase 2 European-American reference panel were examined.

  • GIANT GWAS 2010-2013 Summary Statistics: waist-hip ratio adjusted for BMI ( Database )

    Summary data from the GIANT consortium 2010-2013 meta-analyses of Genome-wide Association (GWA) data include p-values and direction of effect at over 2 million directly genotyped or imputed single nucleotide polymorphisms (SNPs). Allele frequency data was not released to prevent the possibility of identifying individuals from the summary results.

    In the discovery stage, up to 2,850,269 imputed and genotyped single nucleotide polymorphisms (SNPs) were examined in 32 GWA studies comprising up to 77,167 participants informative for anthropometric measures of body fat distribution. SNPs representing the top 16 independent regions of association were evaluated in 29 additional, independent studies (up to 113,636 individuals).

  • GIANT GWAS 2012-2015 Summary Statistics: Age-/Sex-Stratified 2015 BMI and WHR ( Database )

    Summary data from the GIANT consortium 2012-2015 meta-analyses of Genome-wide Association data.

    BMI and waist-hip ratio association stratified by age (over and under 50 years old) and sex.

  • GIANT GWAS 2012-2015 Summary Statistics: Anthropometric 2014 Height ( Database )

    Summary data from the GIANT consortium 2012-2015 meta-analyses of Genome-wide Association data.

    Results are reported from a GWAS meta-analysis of adult height in 253,288 individuals of European ancestry.

  • GIANT GWAS 2012-2015 Summary Statistics: Anthropometric 2015 BMI ( Database )

    Summary data from the GIANT consortium 2012-2015 meta-analyses of Genome-wide Association data.

    Data sets available are:

    BMI Men Only
    BMI Women Only
    BMI European descent
    BMI All Ancestries

  • GIANT GWAS 2012-2015 Summary Statistics: Anthropometric 2015 Waist ( Database )

    Summary data from the GIANT consortium 2012-2015 meta-analyses of Genome-wide Association data.

    Genome wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals were conducted. Each association is stratified by sex (male, female) and ancestry (European, All Ancestries). Secondary GWAS meta-analyses for five additional traits were performed:
    - unadjusted WHR
    - BMI-adjusted waist circumference
    - unadjusted waist circumference
    - BMI-adjusted hip circumference
    - unadjusted hip circumference

  • GIANT GWAS 2012-2015 Summary Statistics: Extremes of anthropometric traits summary statistics ( Database )

    Summary data from the GIANT consortium 2012-2015 meta-analyses of Genome-wide Association data.

    GWAS meta-analysis including up to 263,407 was carried out for the upper vs. lower 5th percentiles of body mass index, height, and waist-to-hip ratio, as well as clinical classes of obesity.

  • GIANT GWAS 2012-2015 Summary Statistics: Sex stratified anthropometrics summary statistics ( Database )

    Summary data from the GIANT consortium 2012-2015 meta-analyses of Genome-wide Association data.

    Sex-specific GWAS was performed for six anthropometric traits involving a total of 270,775 subjects from 94 studies.

  • GIANT GWAS 2012-2015 Summary Statistics: Variability in BMI and Height ( Database )

    Summary data from the GIANT consortium 2012-2015 meta-analyses of Genome-wide Association data.

    A meta-analysis was performed of genome-wide association studies of phenotypic variation for height and BMI in human populations.


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Last updated: 2016-07-13T18:37:44.647-04:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016