International Genomics of Alzheimer's Project

Summary:

The International Genomics of Alzheimer's Project (IGAP) is releasing the summary results data from the 2013 meta-analysis of Genome-wide Association (GWA) data in Alzheimer's disease, in order to enable other researchers to examine particular variants or loci for their evidence of association. The files include p-values and direction of effect at over 7 million directly genotyped or imputed single nucleotide polymorphisms (SNPs). To prevent the possibility of identification of individuals from these summary results, allele frequency data are not released.

Resources:

Databases

• IGAP GWAS: Summary statistics for Alzheimer's disease ( Database )
  

  "Two dataset are provided. The first one corresponds to the meta-analysis results obtained in stage 1 including genotyped and imputed data (7,055,881 single nucleotide polymorphisms, 1000G phase 1 alpha imputation, Build 37, Assembly Hg19) of 17,008 Alzheimer's disease cases and 37,154 controls. The second one corresponds to the meta-analysis results of the 11,632 SNPs that were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls with the combined stage1/stage2 P-values."

Web Links:

• http://web.pasteur-lille.fr/en/recherche/u744/igap/igap_download.php