Established in 2006, The Penn Center for Pulmonary Hypertension Research (CMREF) was formed as a part of nation-wide pulmonary hypertension research network. The CMREF mission is to aid in uncovering the etiology and pathogenesis of many forms of pulmonary arterial hypertension (PAH), in pursuit of the ultimate goal of its treatment and cure. Our Center has been helping to rapidly expand knowledge in PAH research, diagnoses and treatment by providing cells isolated from PAH patients and control subjects. We have successfully isolated different types of vascular cells from over 140 subjects. These materials have been banked and distributed to support the further research for our group as well as on- and off-campus researchers including NIH-R03 recipients to uncover the causes and pathogenesis of idiopathic pulmonary arterial hypertension (IPAH), in pursuit of the ultimate goal of its treatment and cure.