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Mass Spectrometry Facility (Penn)

Director: Ross, Charles W. III., PhD


"The Mass Spectrometry Facility is part of the Shared Instrument Facilities of the Department of Chemistry. It provides low and high resolution mass spectra to Penn Chemistry and to other research groups throughout the university community for the determination of elemental composition and purity of a wide variety of compounds."

Investigators interested in using the facility are encouraged to call and discuss their project. Usage fees will be quoted at this time. Fees depend upon the instrument involved in the analysis, complexity of the project, training, etc.





  • Agilent 5973 GC/MS ( Gas chromatography-mass spectrometry platform )

    "The GCMS is used by researchers to obtain low resolution mass spectra of small volatile compounds (500 amu) or mixtures using the CI method of ionization. The instrument was installed in 2002 and analyzes about 500 samples a year."

  • Bruker MALDI-TOF-TOF ( MALDI-TOF mass spectrometer )

    "This instrument was acquired recently with the purpose of allowing the facility to expand service to its present users and to attract new applications, particularly those of researchers who are doing work at the interface of chemistry and bioscience. This instrument is capable of analyzing peptides, proteins, tRNA, oligonucleotides, and synthetic polymers."

  • Waters GC-TOF Premier mass spectrometer ( Gas chromatography-mass spectrometry platform )

    "The GC-TOF analyzes samples that can be volatilized and detected by use of gas phase CI. This instrument is capable of automated exact mass measurements."

  • Waters LCT Premier XE LC/MS system ( Liquid chromatography mass spectrometry platform )

    "The LCT Premier is a high-resolution orthogonal time-of-flight (oa-TOF) analyzer with both APCI and ESI ionization capability. This instrument may expand from conventional V to W geometry, thereby enhancing resolution. This instrument is capable of automated exact mass measurements."

  • Waters SQD equipped with Acquity UPLC ( Ultra performance liquid chromatography instrument )

    "This is a user operated instrument for obtaining low resolution mass spectra of polar samples using the electro spray ionization (ESI) technique. It is generally used by synthetic organic chemists for rapid survey work in the 150 - 2000 amu range and occasionally for the analysis of larger biomolecules by detection of multiply charged species. Almost every researcher is trained on its use. It is available twenty four hours a day, seven days a week, and analyzes roughly 8000 samples a year."


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Last updated: 2019-12-13T11:39:53.950-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016