The Department of Pharmacology at Penn is one of the oldest and most distinguished in the country, and we are at the forefront of the discipline in the new millennium. We rank first for NIH funding amongst such Departments. Our science uses the tools of molecular and cellular biology, analytical and structural biology and mechanism based clinical investigation to discover and elucidate the action of novel therapeutics. The traditional strength of the Department has been in neuropharmacology. However, in the past decade we have expanded this considerably and have established robust programs in cardiovascular pharmacology and cancer pharmacology. Genomics and proteomics are becoming increasingly important tools throughout the Department. These interests have attracted a large number of faculty with expertise in cell signaling, spectroscopy and models of human disease. The Proteomics Cores of both the Penn Genomics Institute and ITMAT are led by Ian Blair, Vice Chair of the Department, and housed adjacent to Departmental space.