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Mass Spectrometry Molecular Profiling Core (Penn)

Director: Blair, Ian A., PhD


This core provides sophisticated analytical services based on liquid chromatography-mass spectrometry.





  • Thermo Scientific LTQ Orbitrap-XL mass spectrometer with Waters nanoAcquity UPLC system ( Ion trap mass spectrometer )

    "The nanoACQUITY UltraPerformance LC® (UPLC® ) System is designed for nano-scale, capillary, and narrow-bore separations to attain the highest chromatographic resolution, sensitivity, and reproducibility.

    Direct nano-flow offers significant improvements over conventional nano-flow separations technologies. You’ll see improved peak capacity and peak shape, and increase the number of components that can be detected per separation.

    The system’s 10,000 psi operating pressure capability allows for superior high-peak capacity separations by operating longer columns packed with sub-2 micron particles. It is optimized for high-resolution identification and 2D-LC separations at precise nano-flow rates."

    "Thermo Scientific LTQ Orbitrap XL hybrid FTMS (Fourier Transform Mass Spectrometer) supports a wide range of applications from routine compound identification to the most challenging analysis of low level components in complex mixtures.

    The LTQ Orbitrap XL is based on the fast and highly sensitive Thermo Scientific LTQ XL linear ion trap and the proprietary Orbitrap technology. The LTQ Orbitrap XL features a new HCD collision cell for ultimate flexibility in fragmentation experiments for advanced proteomics and small molecule research."


Last updated: 2016-05-11T14:43:53.352-04:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016