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Small Animal Imaging Facility: Nuclear Medicine Sub-Core (Penn)

Director: Karp, Joel S., PhD


The PET Center operates various PET, SPECT, and CT scanners for different research and scanning needs.





  • Computerized veterinary monitoring system ( Animal physiology monitoring system )

    "We also monitor animals using a computerized veterinary monitoring system."

  • Small animal microCT ( Computed tomography scanner )

    "A NIH Shared Instrumentation Grant was used to purchase a small animal microCT scanner from ImTek. This system has a spatial resolution of < 50 mm, and provides anatomical images to complement the PET and SPECT data. A CT scan of each animal can be performed routinely, immediately before or after obtaining the functional PET/SPECT data, to provide accurate image registration for anatomical localization and region-of-interest delineation."

  • Small animal PET scanner ( PET animal imager )

    "A small animal PET scanner (A-PET) is operating in the small animal imaging laboratory, functionally identical to the Philips Mosaic small animal scanner. This system has high spatial resolution (2 mm), with high sensitivity and large transverse imaging field-of-view of 12.8 cm. The imaging aperture is 20 cm and the axial length is 12 cm."

  • Small laboratory animal isoflurane anesthesia system ( Anesthesia machine )

    "We operate an isoflurane anesthesia system (VetEquip Inc., Pleasanton, CA) specifically designed for use with small laboratory animals (rats and mice). The system comprises several induction boxes for the safe initial anesthesia of mice, and custom-made nose-cones for maintaining anesthesia throughout the SPECT session. We also monitor animals using a computerized veterinary monitoring system (Vetronics, West Lafayette, IN)."

  • Trionix Triad XLT9 ( SPECT animal imager )

    "A Trionix XLT-9 system is available for small animal imaging. This system offers list-mode acquisition, and pinhole collimation (0.5, 1.0, 2.0 and 3.0 mm) through adaptation of the existing single-pinhole and multi-pinhole collimators that were used previously on a Picker system. Helical pinhole acquisition is available for whole-body studies or enlarged axial field of view. Parallel-beam and fan-beam collimators are available for larger animals."


  • PET/SPECT/CT image analysis ( Data analysis service )

  • Radiotracer service ( Material production service )

    "There are a variety of radiotracers available, and an additional charge applies depending upon the particular radiotracer used. Please contact Joel Karp at joelkarp@mail.med.upenn.edu for more information."

    "The cyclotron facility houses a Japan Steel Works BC3015, 30 MeV cyclotron and an IBA 18 MeV Cyclone machine. The JSW cyclotron is capable of accelerating p, d, 3He, and 4He. Beam currents of 10-20 mA are typical with a maximum current capability of 30-40 mA. We use protons at 22 MeV to produce 11C, 13N and most 18F-labeled tracers, and deuterons at 11 MeV for 15O, 18F-DOPA and E18F-5, (the latter two are produced from 18F gas). The IBA cyclotron provides for higher beam currents than are available on the JSW machine. Specifically, the 18F- production yield increases from 1.5 Ci to 10 Ci and 11C yield increases from 1 Ci to 2.5 Ci, thereby increasing yields of research tracers. While the JSW can only irradiate 1 target at a time, the IBA is capable of irradiating 2 targets simultaneously."

  • Small animal PET/SPECT/CT imaging ( Access service )


  • AMIDE ( Software )

    "AMIDE is a completely free tool for viewing, analyzing, and registering volumetric medical imaging data sets. It's been written on top of GTK+, and runs on any system that supports this toolkit (Linux, Windows, Mac OS X, etc.)."

  • Amira ( Software )

    "From a reconstructed geometry or from any imported 3D data, including time series, the Basic Amira Package delivers a wide range of visualization techniques and interactive manipulation capabilities. Through a comprehensive set of 3D post-processing tools, it offers a highly flexible and powerful 3D visualization and simulation platform."

  • Matlab ( Software )

  • Statistical Parametric Mapping system ( Software )

    "Statistical Parametric Mapping refers to the construction and assessment of spatially extended statistical processes used to test hypotheses about functional imaging data. These ideas have been instantiated in software that is called SPM.

    The SPM software package has been designed for the analysis of brain imaging data sequences. The sequences can be a series of images from different cohorts, or time-series from the same subject. The current release is designed for the analysis of fMRI, PET, SPECT, EEG and MEG."

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Last updated: 2016-04-28T12:01:23.927-04:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016