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Small Animal Imaging Facility: Ultrasound Sub-Core (Penn)

Director: Sehgal, Chandra (Sandy) M., PhD


The Ultrasound Sub-Core of the SAIF offers an array of research services for pre-clinical research including quantitative image analysis and consultation.

Our state-of-the-art ultrasound scanners are available as a resource for conducting your research studies. This rich resource for ultrasound imaging is available at nominal hourly fees for various categories of study.

Ultrasound Research Services provides services to a host of groups working on diverse projects such as the measurement of angiogenesis, vascularity, tissue elasticity, the effects of various pharmaceuticals on these measures and more. Such research encompasses a variety of clinical areas including radiology, oncology, cardiology, gynecology, and hematology, among others.





  • Philips HDI-5000 ultrasound scanner ( Ultrasound machine )

    "This scanner operates at clinical ultrasound frequencies 4-15 MHz and provides imaging in various modes including fundamental and harmonic grayscale, Color Doppler, power Doppler, spectral Doppler, and M-mode. The scan-heads available for imaging are: C8-5, CL10-5, L12-5, C5-2, L7-4, C8-9, C9-5, C7-4, PQ3, and P4-2. This scanner is most suited to contrast-enhanced ultrasound imaging."

  • VisualSonics Vevo 770™ ultrasound scanner ( Ultrasound machine )

    "A high-frequency scanner designed to scan small animals. The new state-of-the-art scanner provides exquisite high resolution images at ultrasound frequencies of 30-50 MHz. The scanner enables in-vivo assessment of anatomical structures and hemodynamic functions in longitudinal studies.

    The scanner has pulsed-wave Doppler for quantitative blood flow velocity and waveform measurements. The ECG of the animal can be monitored on screen. The M-mode of the scanner monitors tissue motion, which is useful for characterizing blood vessels, heart dynamics and wall thickening. The scanner is equipped with 3D and power Doppler imaging for visualizing blood vessel branching and blood flow patterns spatially and temporally. The scanner's Mouse Handling Platform maintains animal core temperature, and monitors the ECG and other physiological measurements."


  • Blood flow velocity measurement ( Analysis service )

    "Spectral Doppler imaging can provide a variety of measures and indices in both arterial and venous flow."

  • Contrast enhanced sonography ( Analysis service )

    "The use of micro-bubble based contrast agents for enhancing ultrasound images is now FDA-approved for cardiac imaging, and being evaluated for other clinical applications. Ultrasound Research Services has the resources necessary for performing this type of imaging in both fundamental and harmonic modes. The capability for both qualitative and quantitative assessment of such images also exists within Ultrasound Research Services."

  • Quantitative analysis of images ( Data analysis service )

    "All the ultrasound images used for research purposes are recorded on videotapes. There is a facility for labeling individual frames on the tape and digitizing them frame by frame for computer analysis. An extensive software package has been developed in-house that allows semi-automated analysis of large data sets (up to 10,000 images per set) of sonographic and Doppler images. This resource allows monitoring of flow and gray-scale changes at a temporal resolution of 30 ms. The software has a large set of tools for measuring regional and global changes in vascularity and gray scale texture. This computer program is particularly suited for evaluating the kinetic response of the organs to pharmaceuticals."

  • Small animal ultrasound imaging ( Material analysis service )

    Gray-scale, 3D, M-Mode, color Doppler and power Doppler imaging are available using frequencies ranging from 12 MHz to 40 MHz. The latest high frequency technology is available with linear transducers ranging from 30 MHz to 40 MHz. Interventional assistance can be provided with great resolution and accuracy in extremely small and difficult cases.

  • Tissue motion measurement ( Analysis service )

    "M-mode imaging is available for measuring tissue motion in cardiac and other applications."

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Last updated: 2016-04-28T12:35:10.052-04:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016