The Weljie Lab is located in the Department of Pharmacology at the University of Pennsylvania. Our lab is at the forefront of metabolomics technologies to examine biological problems in a translational medicine context.
Metabolomics is a growing sub-field of systems biology centered on the study of small biological molecules in biological fluids and tissues. Recent research suggests that analysis of metabolite concentrations in living systems is useful in disease diagnosis, prognosis, and predicting drug efficacy in a personalized medicine context.
Our focus is on developing analytical methods to advance research in translational medicine. There is an intrinsic link between metabolism and function of the innate circadian clock system in numerous organisms and disease states, but the exact mechanism by which the clock controls mammalian metabolism is poorly understood. Our work seeks to fill this knowledge gap along with identifying biomarkers of cancer and environmental health.
"The Weljie Lab is equipped with a high-resolution 700 MHz NMR spectrometer equipped with 3 and 5 mm TXI probes and a SampleJet autosampler with dedicated cooling enabling robust and stable high throughput acquisition of NMR metabolomics data."
"The Weljie Lab is equipped with a dedicated LC-SPE system coupled to an Gilson liquid handler for purification of low-concentration compounds for NMR analysis."
"The Weljie Lab is equipped with a Waters Xevo G2-S quadrupole time-of-flight mass spectrometer (QTOF) mass spectrometer equipped for both one-dimensional and two-dimensional Acquity UPLC."
"The Weljie Lab is equipped with a Waters Xevo TQD triple-quadrupole mass spectrometer (QqQ) with Acquity ultraperformance liquid chromatography (UPLC)."